Studies on soft-laser therapy

HERPES:

DOUBLE BLIND CROSSOVER TRIAL OF LOW LEVEL LASER THERAPY (LLLT) IN THE TREATMENT OF POST HERPETIC NEURALGIA - HERPES

Kevin C Moore MB ChB FRCA Naru Hira. Parswanath Kramer, Copparam Jayakumar & Toshio Ohshiro
Department of Anaesthesia, The Royal Oldham Hospital,

Post herpetic neuralgia can be an extremely painful condition which in many cases proves resistant lo all the accepted forms of treatment. It is frequently most severe in the elderly and may persist for years with no predictable course. This trial was designed as a double blind assessment of the efficacy of low level laser therapy (LLLT) in the relief of the pain of post herpetic neuralgia with patients acting as their own controls. Admission to the trial was limited to patients with established post herpetic neuralgia of at least six months duration and who had shown little or no response to conventional methods of treatment. Measurements of pain intensity and distribution were noted over a period of eight treatments in two groups of patients each of which received four consecutive laser treatments. The results demonstrate a significant reduction in the pain intensity and distribution following a course of low level laser therapy.
Laser Therapy. 1988; 1: 7.

EFFICACY OF LOW REACTIVE-LEVEL LASER THERAPY (LLLT) FOR PAIN ATTENUATION OF POSTHERPETIC NEURALGIA - HERPES

Osamu Kemmotsu, Kenichi Sato, Hitoshi Furumido, Koji Harada, Chizuko Takigawa, Sigeo Kaseno, Sho Yokota, Yukari Hanaoka and Takeyasu Yamamura
Department of Anaesthesiology, Hokkaido University School of Medicine, N-15, W-7, Kita-ku, Sapporo 060, Japan

The efficacy of low reactive-level laser therapy (LLLT) for pain attenuation in patients with postherpetic neuralgia (PHN) was evaluated in 63 patients (25 males, 38 females with an average age of 69 years) managed at our pain clinic over the past 4 years. A double blind assessment of LLLT was also performed in 12 PHN patients. The LLLT system is a gallium aluminium arsenide (GaAlAs) diode laser (830 nm, 60 mW continuous wave) Pain scores (PS) were obtained using a linear analog scale (0 to 10) before and after LLLT. The immediate effect after the initial LLLT was very good (PS: 0-3) in 26, and good (PS: 7-4) in 30 patients. The long-term effect at the end of LLLT (the average number of treatments 36 +/- 12) resulted in no pain (PS: 0) in 12 patients and slight pain (PS: 1-4) in 46 patients. No complications attributable to LLLT occurred. Although a placebo effect was observed, decreases in pain scores and increases of the body surface temperature by LLLT were significantly greater than those that occurred with the placebo treatment. Our results indicate that LLLT is a useful modality for pain attenuation in PHN patients and because LLLT is a non invasive, painless and safe method of therapy, it is well acceptable by patients.
0898-5901/91/020071-05$05.00 Ì 1991 by John Wiley & Sons, Ltd.

ACNE:

Laser Surgery: How and Why It Works

To understand why the laser works, you must first appreciate some basics about your wrinkles and acne scars. Wrinkles and acne scars share one very important feature: they are lower than the surrounding skin. Because of this, light casts shadows in them, making them visible. Look in the mirror to convince yourself. You will see that everywhere there is a wrinkle or acne scar, there is a shadow. If all wrinkles and acne scars were flush with the level of the skin, the eye would not see them because there would be no shadow. Laser resurfacing works because it makes the wrinkles (acne scars) less visible by vaporizing the surrounding skin (as in the case of CO2 and Erbium) and by stimulating collagen production which makes wrinkles less deep (as in the case of the CO2, Erbium, and N-Lite laser). Because your skin is vaporized (due to the CO2 or Erbium lasers), it is like a true burn. Your skin will be oozing and weeping. The deeper your wrinkles and acne scars, the more treatments you will need. Shallow wrinkles and scars may be vanished with one treatment.

The N-Lite laser is slightly different than the other two in several important ways. First, it does not actually vaporize away the top layer of the skin, so there is no open wound and no recovery period. You may put make-up on immediately and return to work. There is also no discomfort of the procedure, so you do not need to be anesthetized. N-Lite works by stimulating collagen formation within your skin, as opposed to CO2 and Erbium, which work by removing the older superficial skin layers.

Acne Vulgaris

Acne Vulgaris appears in the 12-25 year old population as well as older individuals in the form of 'adult acne'. Most suffer occasional blemishes in the milder form of noninflammatory acne.
Others suffer from inflammatory acne with its lesions consisting of blood vessels, white blood cells, and other materials.
Laser Treatment with the pulse dye laser technology is suited for treatment of acne as it provides for the selective elimination of the small blood vessels that are associated with the inflammation 'redness' of mild to moderate acne. Typically, one to two treatments are recommended. Results are seen in three to four weeks.

Lasers are also effective for Erythematous and Hypertrophic (red and raised) acne scars. It is not effective on atrophic scars (pitted/indented).

American Academy of Dermatology: Laser Treatment of Acne Scars Proves Successful

NEW YORK, August 1, 1997 -- Despite their prevalence, acne scars have been notoriously difficult to treat. Traditionally, dermatologists have used excision, punch grafts, dermabrasion and chemical peels as treatments. But the results of these therapies were limited, and additional scarring could potentially occur. Over the past several years, dermatologists have worked with pulsed laser technology, which has assumed an increasingly important and indispensable role in the treatment of acne scars.
Speaking today at the American Academy of Dermatology's Academy '97 Meeting, at the New York Hilton and Towers, Tina S. Alster, MD, Washington Institute of Dermatologic Laser Surgery and Georgetown University, reported on the increased use of the pulsed lasers in acne scar treatment.

In the late 1980s, experiments using pulsed dye lasers were initiated on thickened, overgrown scars. Dr. Alster and her colleagues reported prolonged improvement in the appearance of most scars after pulsed dye laser treatment. "Clinical assessments and skin surface texture analyses using a computer image analyzer showed that the laser-irradiated scars approximated normal skin characteristics," noted Dr. Alster.
Clinical research over the years has led to textural improvements of both thickened and deeply colored red scars. "After one or two pulsed dye laser treatments, a 57% to 83% improvement was observed. Facial acne scars have been very responsive to this treatment," said Dr. Alster.
Research has shown that combining the use of the pulsed dye technology with carbon dioxide laser vaporization was found to provide improvement in non-reddened, minimally thickened scars. Atrophic acne scars where there is a breakdown of the skin, have been found to respond most favorably to carbon dioxide laser resurfacing. The number of treatments necessary depends on the type of lesion and each individual's collagen and wound healing response. Usually two or more treatments are needed for hypertrophic (thick) acne scars.
"We have had great success with these laser treatments, but it is often difficult to categorize scars where several clinical features overlap. A careful preoperative patient evaluation is very important in order to decide the most appropriate procedure to perform," Dr. Alster said.
The pulsed dye laser procedure is typically performed on an outpatient basis without general anesthesia. Local anesthesia is usually administered with a topical anesthetic cream, intralesional injections or nerve blocks. Adjacent, nonoverlapping laser pulses are delivered over the scars. The immediate result may produce a purplish coloring. The treated scars are then evaluated 6-8 weeks later, where another treatment, at the same or slightly higher strength may be necessary.

Local, regional nerve block, or intravenous sedation may be required for CO2 laser resurfacing of atrophic acne scars depending on the extent of damage. Follow-up examinations and skin cleanings are scheduled often during the first postoperative week and patients are encouraged to keep the area moistened with healing ointments and/or cooled compresses. Early evaluation and intervention are important in order to prevent long-term scarring.

"Great strides have been made in the treatment of acne scarring. Pulsed dye lasers are now the preferred treatment for red or thick scars, whereas carbon dioxide laser resurfacing for atrophic scars is now surpassing the results obtained from dermabrasion and chemical peels. Future laser technologic advances coupled with other treatments may even further enhance clinical results," Dr. Alster said.
The American Academy of Dermatology is the largest medical society representing physicians who specialize in treating skin, hair and nail conditions.

Study Finds New Laser Treatment Helps Heal the Physical and Emotional Scars of Acne
by AAD

Acne is a common medical condition that affects up to 80 percent of people between 11 and 30 years of age.

Press Release from the American Academy of Dermatology

ANAHEIM, CALIF. (July 31, 2001) – Acne is a common medical condition that affects up to 80 percent of people between 11 and 30 years of age. Even after the unsightly whiteheads, blackheads and pustules have been successfully treated, many people are left with disfiguring acne scars that serve as a cruel reminder of this difficult condition. Oftentimes, the scars can be just as devastating as the acne they replaced.

Speaking today at Academy 2001, the American Academy of Dermatology’s summer scientific meeting in Anaheim, Calif., dermatologist Mitchel Goldman, MD, Associate Clinical Professor, Department of Medicine, Division of Dermatology, University of California at San Diego, discussed results of his study on patients treated with a new laser surgery option for acne scarring, as well as other common treatments.
A new device known as the 1320 nm Nd: YAG laser with dynamic epidermal cooling shows promising results in treating acne scarring. The only infrared laser systems cleared by the Food and Drug Administration for treating wrinkles, this non-invasive laser technology works by stimulating collagen formation in the dermis – or deepest layer of the skin – which raises the acne scar.

In a study conducted by Drs. Goldman, Elizabeth Roston and Richard Fitzpatrick, 14 patients with depressed acne scars were treated with a 1320 nm Nd: YAG laser over four separate treatments spaced three weeks apart. By the end of the last treatment, seven patients experienced a 50 percent improvement in the appearance of their acne scars. Improvement was defined as how much the depressed acne scars were elevated following treatment. All patients showed an average 40 percent improvement in the appearance of their acne scars.

"The 1320 nm Nd: YAG laser is an excellent new method for treating acne scars because it works for all skin types – from very dark to very light – and with no downtime," explained Dr. Goldman. "Until now, many of the other acne scar treatments produced a wound that may have required weeks to heal. Since this new laser therapy is non-invasive, the patient does not require anesthesia and the procedure is not a painful one."
Other lasers, such as the pulse dye laser and intense pulse light, also work in elevating depressed acne scars by penetrating the dermis and producing new dermal collagen to elevate the depression. The pulse dye laser produces a bruise that can last one to two weeks. In addition, the Erbium:YAG laser allows for very precise sculpting of acne scars. With this laser, recovery times are faster – usually three to five days – with a shorter period of post-surgery redness than with the CO2 laser for acne scar correction.

Dermabrasion is another effective method to treat acne scars that involves the mechanical sanding of the upper layers of the scar. With this procedure, a new layer of skin replaces the abraded skin during healing, resulting in a smoother appearance. Although dermabrasion is an invasive procedure that requires anesthesia, most patients heal within one to two weeks.

For severely depressed scars, more invasive techniques are required. Subcision is a procedure that uses a surgical probe to lift up the skin that pulls away from the depressed scar tissue below. After the scar is released, the patient’s own fat or another substance like collagen can be used to elevate the scar.

"Acne scars that require surgical excision are usually followed by laser resurfacing or dermabrasion to erase the surgical excision line," added Dr. Goldman.

Another type of acne scarring is elevated scars, which are usually red in appearance. Lasers, such as the pulse dye laser and intense pulse light, work by eliminating the excessive blood vessels that give elevated scars their appearance. Elevated scars can also be treated with injections of intralesional 5% 5-FU, which works by breaking down the scar causing the acne scar to flatten. Intralesional 5% 5-FU is preferred over steroids because it does not cause a depression or the formation of new blood vessels that steroids can.

Patients with very mild acne scarring are also good candidates for microdermabrasion, a technique in which aluminum oxide, and silicon or salt crystals passing through a vacuum tube gently scrapes away the scarred skin. With this procedure, new cell growth is stimulated. While microdermabrasion is a quick procedure that leaves the patient with only minimal redness, patients will often require multiple treatments and the results are not as dramatic as other procedures.

"Today, patients have more options than ever to treat acne scars," said Dr. Goldman. "Dermatologists can help patients choose the best treatment options for their particular kind of acne scars. Acne scarring no longer has to be a constant reminder of the physical and emotional pain that accompanies acne."

The American Academy of Dermatology, founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of over 13,000 dermatologists worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; supporting and enhancing patient care for a lifetime of healthier skin. For more information, contact the AAD at 1-888-462-DERM or www.aad.org.

WRINKLES:

Wrinkle Erasers
(press release from PRWEB)

The dreaded wrinkle. The discovery of one is enough to send you straight into solitude. But before you go into hiding, try one of these: The dream team of skin rejuvenation treatments. From IPL to Aramis Laser, these non-surgical treatments can now give you a little lift.
Singapore - September 12, 2004 -- Even though aging is inevitable, we can make the decision to either have our skin age slowly and gracefully, or have skin looking like an old leather armchair by the time we're forty.

Sun damage is the main culprit for aging that show up on our face, and can be visible as early as our late twenties! Another big factor in the aging force is smoking, whether you smoke or are around second hand smoke.

One solution to prevent aging is to throw away that cigarette, stay out of the sun, and slather on generous helpings of that sunblock daily. The other is to indulge your skin in the latest skin rejuvenation techniques that will shed years off your face without going under the scalpel.

The newest trend in laser skin therapy today is Non-Ablative Laser Collagen Replacement, accomplishing the same long-term result in restoration and increased collagen production in the dermis, but without the downtime, the redness and other side effects of the older, more invasive laser procedures. Aesthetic physician, Dr. Low Chai Ling, is one of the first few doctors in Singapore to use the Aramis Laser for replacing collagen in aging faces.

“Aramis laser is excellent for my patients who want to plump up their faces, and lessen their lines without surgery, needles and most of all, without downtime. It is an easy, quick and gentle way to look younger. Most of my patients have really caught on to the idea of (Non-Ablative Laser) Collagen Replacement.”

“A series of cool, gentle pulses over the entire face and the treatment is over in less than half an hour. I usually finish it off with some deep vitamin therapy to improve the end results. The patient leaves with no redness or peeling, and usually begins to see results after a series of about 6 sessions, some even sooner.”

In the Journal of Dermatologic Surgery: Profilometric Evaluation of a 1540 nm Er:Glass Laser.,Dermatologic Surgery 27 (9), 799-806, the Aramis laser was reviewed for efficacy in the treatment of wrinkles. In this study 60 patients were treated four times with the Aramis laser. Digital Photographs, Ultrasound Imaging, Silicone Imprints of the Wrinkles and Skin Biopsy studies were performed. All subjects showed marked improvement in wrinkles by all techniques studied with no downtime or pain, redness, swelling, burning, skin irritation, photosensitivity or any adverse effect to the procedure. Quite an excellent result for something so simple and elegant to perform!

For those who want even greater results, Dr. Low says that the Aramis laser’s effect of skin remodeling can be significantly augmented by following a prescribed schedule of procedures and skin care therapies.

“In our practice we have developed a "Scalpel-less" face-lift protocol for wrinkle reduction without pain, redness and healing time. We combine the latest Aramis Laser rejuvenation with a series of microdermabrasion for the added skin smoothing effect, pumpkin face peels for the amazing Vitamin C delivery and sometimes a few sessions of IPL to clear out any uneven skin tone in an instant. The patient looks dramatically younger and fresher when she walks out of the door after our program is completed.”

“Even younger patients who look tired or dull have jumped onto this new “Scalpel-less” face lift program to look even better. I guess the young ladies nowadays do not want to wait until they are old and wrinkled before doing something for themselves.”

Too good to be true? There’s more. The Aramis Laser is also touted to improve acne and acne scarring. The Aramis laser produces a sub-coagulative thermal injury leading to a temporary alteration in the size and function of the overactive sebaceous gland. This thermal effect kills bacteria and reduces sebum (oil) production, paving the way for clearer skin. The added collagen remodeling effect is also beneficial for acne scarring. Patients who have had to live with their acne scars can now look to the Aramis laser for some reprieve.

The price tag for beauty? Aramis laser starts at about US$350 per session. For those who may balk at paying such a price for beauty, there are still creams and potions you can slather on your face. Dr. Low recommends Skin Inc’s Skin Rejuvenation Serum. This fountain of youth serum is supposedly pure magic. Sodium silicate adheres to the skin, helping to shrink lines and pores into perfection. Fine lines and wrinkles instantly disappear before your eyes. The other sought after product is Physician’s Choice Exlinea Peptide Smoothing Serum. It apparently contains hyaluronic acid for a firmer, plumper complexion. What’s the catch? These products do not work as well without the treatments, and as they are prescription only products, a consultation with the doctor is necessary.

But it’s still worth a try for those of us who just want a small sip from that fountain of youth!

Dr. Low Chai Ling can be contacted at The Sloane Clinic in Singapore on 65-6533 2522 or visit: www.sloaneclinic.com
Ultrapulse carbon dioxide laser removal of periocular wrinkles in association with laser blepharoplasty.

Weinstein C.

Freemasons Day Procedure Centre, East Melbourne, Victoria, Australia.

Removal of periocular wrinkles is a common yet difficult problem. There are many techniques currently available, all of which have some drawbacks. With the advent of new generation ultrapulse carbon dioxide lasers, skin can now be resurfaced successfully with minimal risk and side effects. In our study of 36 patients we assessed the benefit of using ultrapulse carbon dioxide (CO 2) laser to resurface the periorbital skin in association with transconjunctival lower lid CO 2 laser blepharoplasty. We found that 36/36 (100%) patients had good to excellent results. The incidence of side effects was very low. We also found that 2/36 (5.6%) of patients developed mild clinically insignificant hypopigmentation and 1/36 (2.8%) developed mild scarring, which resolved with one injection of triamanalone 10 mg/ml. No patients had hyperpigmentation. In addition, 1/36 (2.8%) patients developed transient ectropion, which resolved spontaneously in 6 weeks. We conclude that ultrapulse CO 2 laser is an excellent method for treating periocular wrinkle lines and can be readily performed in conjunction with a transconjunctival lower lid blepharoplasty.

PMID: 10147479 [PubMed - indexed for MEDLINE]

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Sasaki K. et al. A double-blind controlled study on free amino acid analysis in CO2 laser burn wounds in the mouse model following doses of low incident infrared (830 nm) diode laser energy.
Proc. 2nd Meeting of the Internat Laser Therapy Assn., London, 1992, p.4.

Sasaki K. et al. A preliminary double blind controlled study on free amino acid analysis in burn wounds in the mouse following 830 nm diode laser therapy.
Laser Therapy. 1997; 2 (9): 59-65.
Sato K. et al. A double blind assessment of low power laser therapy in the treatment of postherpetic neuralgia. Surgical and Medical Lasers. 1990; 3 (3): 134 (abstract)
Saunders L. The efficiacy of low-level laser therapy in supraspinatus tendinitis.
Clin Rehab. 1995; 9: 126-134
Schindl A. et al. Low intensity laser irradiation improves skin circulation in patients with diabetic microangiopathy. Lasers Surg Med. 1998; Suppl. 10: 7.
Scudds R. A. et al: A double-blind crossover study of the effects of low-power gallium arsenide laser on the symptoms of fibrositis. Physiotherapy Canada. 1989; 41: (suppl 3): 2.
Simunovic Z., Trobonjaca T. et al. Treatment of medial and lateral epicondylitis - tennis and golfer elbow - with low level laser therapy: a multicenter double blind, placebo controlled clinical study on 324 patients.
J Clin Laser Med & Surg. 1998; 16 (3): 145-151.
Simunovic Z., Trobonjaca T. Soft tissue injury during sport activities and traffic accidents - treatment with low level laser therapy. A multicenter double blind, placebo controlled clinical study on 132 patients.
Proc. IXX ASLMS Congress, Orlando, Florida, April 1999.
Snyder-Mackler L. et al. Effect of helium-neon laser on musculoskeletal trigger points.
Physical Therapy. 1986; 66: 1087.
Snyder-Mackler L. et al. Effect of helium-neon laser irradiation on peripheral sensory nerve latency.
Physical Therapy. 1988; 68: 223.
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Soriano F. A. et al Acute cervical pain is relieved with gallium-arsenida (GaAs) laser irradiation. A double-blind preliminary study. Laser Therapy. 1996; 8: 149-154.
Soriano F. A. et al. Low level laser therapy response in patients with chronic low back pain.
A double blind study.Lasers Surg Med. 1998, Suppl. 10, p. 6.
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Laser Therapy 1994; 6:143.
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Clinical Laser Med Surg. 1991; 2(9): 143.
Tsurko V. et al. Laser therapy of rheumatoid arthritis.
A clinical and morphological study. Terap Arkh. 1983; 97. (Russian).
Volez-Gonzalez M. et al. Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudenda" with low power HeNe-laser or Acyclovir administered orally. SPIE Proc. 1995; Vol. 2630: 43-50
Vasseljen O. et al. Low level laser versus placebo in the treatment of tennis elbow.
Scand J Rehab Med. 1992; 24: 37. Also in Physiotherapy. 1992; 5: 329.
Walker J. Relief from Chronic Pain by Low Power Laser Irradiation.
Neuroscience Letters. 1983; 43: 339
Walker J. Temporary suppression of clonus in humans by brief photostimulation
Brain Research. 1985; 340: 109.
Walsh D. et al. The effect of low intensity laser irradiation upon conduction and skin temperature in the superficial radial nerve. Double-blind placebo controlled investigation using experimental ischaemic pain. Proc. Second Meeting of the Internat Laser Therapy Association, London, sept. 1992.
Willner R. et al. Low power infrared laser biostimulation of chronic osteoarthritis in hand.
Lasers Surg Med. 1985; 5: 149.
Wylie L. et al. The hypoalgesic effects of low intensity infrared laser therapy upon mechanical pain threshold. Lasers Surg Med. 1995; Suppl 7:9.
Yamaguchi M. et al. Clinical study on the treatment of hypersensitive dentin by GaAlAs laser diode using the double blind test. Aichi Gakuin Daigaku Shigakkai Shi - Aichi-Gakuin Journal of Dental Science. 1990; 28( 2): 703-707. (in Japanese)

2. Other scientific works

G. Danhof
(ISBN 3-921988-50-0) Lasertherapie in der Allgemeinmedizin
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G. Dahof
(ISBN 3-87569-083-4) Lasertherapie in der Sportmedizin
(WBV Biologisch-Medizinische Verlagsgesellschaft, 73614 Schorndorf)
G.Stux, N.Stiller, B.Pomeranz Akupunktur – Lehrbuch und Atlas
(5. Auflage Springer-Verlag, 1998)
Pekka J. Pöntinen,
Raymund Pothmann
(ISBN 3-7773-1019-0) Laser in der Akupunktur
(Hippokrates Verlag GmbH, Stuttgart)
TECHNICA-PRO The use low-energy Laser in the clinic of inner diseases
(http://www.gamma.ru/technica/articles-1/LLLT-2.htm)
S. Allemann Softlaser in Medizin und Kosmetik
Laserakupunktur und Lasertherapie
Kombinationstherapie mit dem System Ottenburg
(http://www.ottenburg.ch/softlaser/Softlaser.htm)
X. Xiaoa, J. Donga, X. Chua, J-L. Jiaob, S. Jiaa,
X. Zhengha, C. Zhoua, T. C-Y. Liucd, S-H. Liub A single photon emission computer tomography Study of the Therapy of intravascular low intensity laser irradiation on blood for brain infarction
(http://www.pgtconsultants.com/lll_clin_res.pdf)
Pekka J. Pöntinen
(ISBN 951-96632-0-7) Low Level Laser Therapy as a Medical Treatment Modality
(Art Urpo Ltd 1992)
Wersch / Schrecke /
Küstner
(ISBN 3-92-1988-39-X) Akupunkturatlas
(WBV Biologisch-Medizinische Verlagsgesellschaft, 73614 Schorndorf)
Gerhard Leibold
(ISBN 3-635-6005-9) Akupressur
(Flaken-Taschenbuchverlag)
F. Gallo (1998) Energy psychology: Explorations at the interface of energy, cocnition, behavoir and health
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F. Gallo (2000) Energy diagnostic and treatment methods
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J. Bahn Laser und Infrarotstrahlen in der Akupunktur
(Haug Verlag Heidelberg 1984)
J. Bahn Soft Laser und Kybernetik
(Laser-Symposium München 1986)
J. Bahn 6 Jahre Erfahrung in der Lasertherapie
J. Bischko Laser in der Akupunktur
O. Bergsmann Analyse der Laserwirkung mit dem bioelektrischen Funktionsdekoder-LHK
(Erfahrungsheilkunde 25, 1976/3)
R. Bucek Lasertherapie in HNO
(Vorträge Lasersymposium München 1986)
W. Chiaying Experimentelle Studie über die Wirkung der Akupunkturanalgesie mit HeNe-Laser
S. Chelbarov Laser in der Kosmetik
Dinstl / Fischer Der Laser
(Grundlagen und klinische Anwendung)
M. Fischer Die Elektrostimulationsanästhesie und ihre klinische Anwendung
M. Fischer Elektrostimulationsanästhesie bei Eingriffen an den Extremitäten
L.A. Funke Laserakupunktur, eine Alternative in der Schmerztherapie
(Akupunktur, Theorie und Praxis 4/86)
J.H. Gleditsch Biophysikalische Behandlung von Rhinitis und Sinusitis mit Laser
(Vortrag Tokio 1976)
Goldmann Laser in Medicine
Hachenberger Laserstrahlen bei Herpeserkrankungen
(Ärztliche Kosmetologie 1981)
Kovaces Stimulation or wound Healing with Laser Beam in the Rat
M. Krötlinger Zur Anwendung des Lasers in der Akupunktur

W. Kroy Der Einsatz von Lasern in der Medizin
J. Kryspin Medizinische Schmerzbehandlung durch Laser
(Vorlesung Univ. Toronto 1985)
H. Liertzer Laserakupunktur
E. Macheret Laserakupunktur bei der Behandlung der Neuralgien
(Neue Behandlung der russischen Schule, Lasersymposium München)
Mester et al. Untersuchung über die Wirkung der Laserstrahlen auf die Wundheilung
E. Mester Experimentelle und klinische Beobachtungen mit Laserstrahlen
Bihari I., Mester A. The biostimulative effect of low level laser therapy.
(randomized double blind comparative study / 1989; 1(2): 97)
Pischinger Das System der Grundregulation
A. Rachichev Biologische Wirkung der Laserstrahlen
(Alma Ata 1976)
Rother Grundlagen der Anwendung des Lasers in der Medizin
W. Schjelderup Historische und theoretische Grundlagen der Lasertherapie
(Vortrag Lasersymposium München 1986)
Schmidt et al. Promotion of Wound Healing by Using a HeNe Laser
Schumacher Laserakupunktur der Nasenhöhlen
Schumacher Chronische Sinusitis im Kindesalter
(Thermographische Untersuchung vor und nach der Lasertherapie)
Seipp / Haina / Justen
Waidelich Laserstrahlen in der Dermatologie
Abergel P. et al Control of connective tissue metabolism by lasers: Recent developments and future prospects. Journal of The American Academy of Dermatology. 1984; 11: 1142.
Basko I. A New Frontier: Laser Therapy. Calif Veterinarian.1983; 10: 17.
Beck-Friis J., Borg G., Wetterberg L. Rebound increase of nocturnal melatonin levels following evening suppression by bright light exposure in healthy men: relationship to cortisol levels andmorning exposure.
Wurtman RJ, ed. The Medical and Biological Effects of Light. Ann. NY Acad Sci. 1985; 453: 371-375.
Berki T. et al Biological Effect of Low-power Helium-Neon (HeNe) Laser Irradiation.
Lasers in Medical Science. 1988; 3: 35.
Bihari I., Mester A. The biostimulative effect of low level laser therapy of long-standing crural ulcer using Helium Neon laser, Helium Neon plus infrared lasers and non coherent light: Preliminary report of a randomized double blind comparative study. Laser Therapy. 1989;1(2):97.
Bossy J. et al In Vitro Survey of Low Energy Laser Beam Penetration in Compact Bone.
Faculte de Medecine et CHRU de Nimes, BP 26, 3000 NIMES, France. (1985).
Calderhead G. Meeting report. Ninth congress of the International Society for Laser Surgery and Medicine, Anaheim, California, USA: 2-6 November 1991. Laser Therapy. 1992; 4(1): 43.
Cherry R: Measurement of Protein Rotational Diffusion in Membranes by Flash Photolysis.
Methods in Enzymology. 1978; (54):47.
Derr V. E. et al: Free radical occurrence in some laser-irradiated biologic materials.
Federal proc. 1965; 24, No 1, Suppl. 14: 99
Guang Hua Wang et al: A study on the analgesic effect of low power HeNe-laser and its mechanism by electrophysiological means.
Lasers in Dentistry. Excerpta Medica. Elsevier Science Publishers. 1989: p. 277.
Haina D. et al: Animal Experiments on Light-Induced Woundhealing.
Proc from Laser-81, Opto-Elektronik in München 1981.
Hong J. et al: Clinical trial of low reactive-level laser therapy in 20 patients with postherpetic neuralgia.
Laser Therapy.1990; 2(4): 167.
Honmura A. et al: Analgesic Effect of Ga-Al-As Diode Laser Irradiation on Hyperalgesia in Carrageenin-Induced Inflammation. Lasers in Surg Med. 1993; 13: 463.
Hort O, Vanpel T: Die Verteilung von Na+ und K+ unter dem Einfluss von Temperaturgradienten.
Pfluegers Arch. 1971;323:158.
Horvath Z. et al: Possible ab-initio explanation of laser "biostimulation" effects.
Laser applications in medicine and surgery.
Edited G. Galetti et al: Proc 3rd World Congr - Intl Soc Low Power Laser Appln in Medicine 1992. Page 57.

Kaihøj P: Low Level Lasers Effekt på Følsomme Tandhalse - en klinisk pilottest.
Odont Pract. 1991; 6(2): 229.
Karu T., Andreichuck T., Ryabykh T. Supression of human blood chemiluminescence by diode laser irradiation at wavelengths 660, 820, 880 or 950 nm. Laser Therapy. 1993; 5: 103.
Karu T: Photobiological Fundamentals of Low Power Laser Therapy.
IEEE Journal of Quantum Electronics. 1987; QE23(10): 1703.
Karu T. et al: Biostimulation of HeLa-cells by low-Intensity Visible Light.
Il Nuovo Cimento. 1982; Vol 1D, N. 6: 828.
Karu T. et al: Biostimulation of HeLa Cells by Low-Intensity Visible Light.
Il Nuovo Cimento. 1982; 1D(6): 828.
Kerns T: HeNe Lasers Show Promise in Treating Equine Injuries.
Lasers & Applications. 1986; Dec: 39.
Kovacs I. et al: Laser-Induced Stimulation of the Vascularization of the Healing Wound.
Separatum EXPERIENTIA. 1974; 30: 341
Kubota J, Ohshiro T: The effects of diode laser low reactive-level laser therapy (LLLT) on flap survival in a rat model. Laser Therapy. 1989; 1(3): 127.
Kudoh Ch. et al:
Effects of 830 nm Gallium Aluminium Arsenide Diode Laser Radiation on Rat Saphenous Nerve. Sodium-Potassium-Adenosine Triphosphatase Activity: A Possible Pain Attenuation Mechanism Examined.
Laser Therapy. 1989; 1(2): 63. Landthaler M et al: Behandlung von Zoster, postzosterischen Schmerzen und Herpes simplex recidivans in loco mit Laser-Licht.
Fortschr. Med. 1983; 101(22):1039.
Lubart R. et al: A possible Mechanism of Low Level Laser -Living Cell Interaction.
Laser Therapy. 1990; 2(2): 65.
Manne J: Le laser arseniure de gallium 6 watts, etude clinique en odonto-stomatologie.
Le Chirurgien Dent de France 1985; 284:15.
Maricic B et al: Analgetic effect of laser in dental therapy.
Acta Stomat Croat. 1987; 21(4): 291.
McKibbin L. and
Paraschak D: A Study of the Effects of Lasering on Chronic Bowed Tendons at Whitney Hall Farm Limited, Canada, January, 1983. Lasers in Surgery and Medicine. 1983; 3: 55.
Mester E. et al: Untersuchungen ueber die hemmende bzw. foerdernde Wirkung der Laserstrahlen.
Arch Klin Chir. 1968; 322: 1022.
Mester E. et al: Auswirkungen direkter Laserbestrahlung auf menschliche Lymphozyten.
Arch Dermatol Res. 1978; 5: 31
Mester E. et al: The Biostimulating Effect of Laser Beam.
Proc from Laser - 81, Opto-Elektronik in München 1981.
Mizokami T. et al: Effect of diode laser for pain:
A clinical study on different pain types. Laser Therapy. 1990;2 (4):171.
Montesinos M. et al: Experimental Effects of Low Power Laser in Encephalin and Endorphin Synthesis.
LASER. Journ Eur Med Laser Ass. 1988; 1(3): 2.
Moore K. et al: LLLT treatment of post herpetic neuralgia. Laser Therapy.1988; Pilot issue (1):7.
Muldiyarov P. et al: Effect of Monochromatic Helium-Neon Laser Red Light on the Morphology of Zymosan Arthritis in Rats. (Inst. of Rheumatism, Academy of Medical Sciences of the USSR, Mosc). Biull Eksp Biol Med. 1983, Jan 95; 1: 55.
Naeser M. et al Carpal Tunnel Syndrome- Clinical Outcome following Low-Level Laser Acupuncture, Microamps TENS and other Alternative Therapies
Journal of Alternative and Complementary Medicine Vol. 4, No 4, Nov. 1998
Nasu F. et al: Cytochemical Effects of GaAlAs Diode Laser Radiation on Rat Saphenous Artery Calcium Ion Dependent Adenosine Triphosphatase Activity.
Laser Therapy. 1989; 1(2): 89.
Oulamara A. et al: Biological activity measurement on botanical specimen surfaces using a tempral decorrelation effect of laser speckle. Journal of Modern Optics. 1989;36(2):165.
Parascandolo S. et al: Azione della Laser-terapia nella nevralgia essenziale del trigemino.
Int Congress on Laser in Med and Surg, Bologna June 1985, p 317. Monduzzi Editore S.p.A.,Bologna, Italy.
Parrado C. et al: Quantitative study of the Morphological Changes in the Thyroid Gland Following IR Laser Radiation. Lasers in Med Sciences. 1990; 5: 77.

Passarella S. et al: Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser.
FEBS Letters. Sept 1984; 175(1): 95.
Popova M. et al: Effect of Helium-neon laser beam in regeneration of irradiated transplanted skeletal muscle.
Bull Exp Biol Med. 1978; 80: 333. (ryska m eng abstr.)
Pourreau-Schnider N. et al: Helium-Neon Laser Treatment Transforms Fibroblasts into Myofibroblasts.
American Journal of Pathology. 1990; 137: 171.
Rochkind S. et al: A single transcutaneous light irradiation to injured peripheral nerve; comparative study of different wavelengths. Las. in Med Sci. 1989; (4):259.
Rochkind S. et al: Systemic Effects of Low-Power Laser Irradiation on the Peripheral and Central Nervous System, Cutaneous Wounds and Burns. Lasers in Surgery and Medicine. 1989; 9: 174.
Rochkind S. et al: Electrophysiological Effect of HeNe Laser on Normal and Injured Sciatic Nerve in the Rat.
Acta Neurochir. (Wien). 1986; 83: 125.
Shiroto C. et al: Effects of diode laser radiation in vitro on activity of human neutrophils.
Laser Therapy. 1989; 1(3):135. Editore S.p.A., Bologna, Italy
Shiroto C. et al: Retrospective study of diode laser therapy for pain attenuation in 3635 patients:
Detailed analysis by questionaire. Laser Therapy. 1989; 1(1): 41.
Spanner D.C: The active transport of water under temperature gradient.
Symp. Soc. Exp. Biol. 1954;8:76.
Velez-Gonzalez M. et al: Treatment of relapse in herpes simplex on labial and facial areas and of primary herpes simplex on genital areas and "area pudendaö with low power HeNe-laser or Acyclovir administred orally
von Ahlften U et al: SPIE Proc. 1995; Vol. 2630-42: Erfahrungen bei der Behandlung aphtöser und herpetiformer Mundschleimhauterkrankungen mit einem neuen Infrarotlaser. Die Quintessenz. 1987; 5: 927.
Wakabayashi H. et al: Effect of Irradiation by Semiconductor Laser on Responses Evoked in Trigeminal Caudal Neurons by Tooth Pulp Stimulation. Lasers in Surg Med. 1993; 13: 605.

Walker J. et al: Laser Therapy for pain of trigeminal neuralgia. Clin J Pain 1988; 3:183.
Walker J: Relief from Chronic Pain by Low Power Laser Irradiation.
Neuroscience Letters. 1983; 43: 339.
Wakabayashi H. et al: Treatment of dentine hypersensitivity by GaAlAs soft laser irradiation.
J Dent Res. 1988; 67: 182.
Wang L. et al: A Review of Clinical Applications of Low Level Laser Therapy in Veterinary Medicine.
Laser Therapy. 1989; 1(4): 183.

 

3. Weitere Veröffentlichungen

ISBN 953-6059-30-4 Lasers in Medicine and Dentistry
Basic Sience and up-to-date Clinical Application of Low Energy_Level Laser Therapy
Proceedings 2nd Congress World Association for Laser Therapy
Kansas City Missouri September 2-5, 1998
G. David Baxter
Churchill Livingston
ISBN 0-443-04393-0 Therapeutic Lasers
Theory and Practice, 1997
Kert & Rose Scandinavian
ISBN 87-983204-1-6 Clinical Laser Therapy
Low Level Laser Therapy, Medical Laser Technology
Margaret A. Naeser, Ph. D. and Xiu-Bing Wei, MD (China) Laser Acupuncture
Introductory Textbook for Treatment of Pain, Paralysis, Spacticity, and other Disorders
Jan Tuner and Lars Hode
ISBN SE 91-630-4078-6 Laser Therapy in Dentistry and Medicine
Prima Books AB 1996
Dennis Tucker, PhD, DAc Laser and Electrodiagnostic Techniques for the Isolation and Treatment of Odontogenous Foci
American Journal of Acupuncture, Vol 18, No.4, 1990
Jan Tuner and Lars Hode
ISBN 91-630-7616-0 Low Level Laser Therapy
Clinical Practice and Scientific Background, by Prima Books 1999